General Information

  • ID:  hor005016
  • Uniprot ID:  P41989
  • Protein name:  Melanotropin gamma
  • Gene name:  NA
  • Organism:  Theromyzon tessulatum (Duck leech)
  • Family:  POMC family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Theromyzon (genus), Glossiphoniidae (family), Rhynchobdellida (order), Hirudinea (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YVMGHFRWDKF
  • Length:  11(1-11)
  • Propeptide:  YVMGHFRWDKF
  • Signal peptide:  NA
  • Modification:  T11 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005016_AF2.pdbhor005016_ESM.pdb

Physical Information

Mass: 166427 Formula: C72H96N18O15S
Absent amino acids: ACEILNPQST Common amino acids: F
pI: 9.3 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -54.55 Boman Index: -1837
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 26.36
Instability Index: 4401.82 Extinction Coefficient cystines: 6990
Absorbance 280nm: 699

Literature

  • PubMed ID:  8026574
  • Title:  Isolation and structural characterization of a novel peptide related to gamma-melanocyte stimulating hormone from the brain of the leech Theromyzon tessulatum.